Philipp Lachenmann: DELPHI Rationale


Young Investigator Award 2009

Dr. Andreas Ladurner

European Molecular Biology Laboratory Heidelberg

Chromatin dynamics induced by cellular NAD metabolite signaling

Andreas Ladurner has contributed in particular to our understanding of the molecular mechanisms of signal transduction in the cell nucleus. Two groundbreaking pieces of research and a skilled combination of a variety of structural, biochemical and cell biological methods characterize the originality of his work.

The human genome is folded into a compact structure by special proteins, so-called histones. Depending on the cell’s growth conditions, histones are chemically modified by a series of enzymes. Andreas Ladurner identified the first example of a protein that can interpret these chemical modifications.

Recently, his working group also succeeded in showing the dynamic response of the human genome and its proteins to DNA damage.



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