Philipp Lachenmann: DELPHI Rationale


Ernst Schering Prize 2010

Prof. Sir Marc Feldmann and

Prof. em. Sir Ravinder Maini

On September 28, 2010, the Ernst Schering Foundation in Berlin will award this year’s Ernst Schering Prize for international excellence in the field of medicine and basic biological and chemical research. For the first time, the award goes to two scientists. The prize winners are Emeritus Professor em. Sir Ravinder N. Maini and Professor Sir Marc Feldmann from the Kennedy Institute of Rheumatology at Imperial College London, who will be honored for their fight against rheumatoid arthritis and other autoimmune diseases.

A key feature of their work has been the close and fruitful long-term collaboration and the overlap in skills and interests. This has probably helped them to be leaders in the difficult process of translating laboratory research into real medical progress for patients.

About the research work of Marc Feldmann and Ravinder Maini

Ravinder Maini and Marc Feldmann have worked together since the early 1980s to unravel the molecular basis of a major autoimmune disease, rheumatoid arthritis. They discovered a new approach to therapy that has benefitted millions of patients worldwide.

The important research which Feldmann and Maini and their group has performed led to the development of a family of new drugs blocking a host defence molecule, tumor necrosis factor, abbreviated TNF, which controls inflammation and tissue destruction not only in rheumatoid arthritis but also in psoriatic arthritis, ankylosing spondylitis, psoriasis, Crohn’s disease, and ulcerative colitis.

The TNF blocking drugs, either monoclonal antibodies or TNF receptor fusion protein, are effective in the majority of patients, even those refractory to all previous treatments, and are now used by patients with the more severe forms of these diseases. Of particular importance is that joint destruction is halted and the quality of life much improved, so that these drugs are highly appreciated by patients.

For more information on the research work and on the biography of the prize winners, please see the press release.

Important Dates

Award ceremony “Ernst Schering Prize 2010”
September 28, 2010, at 6 p.m. in Berlin, by invitation only

Press conference with the prize winners
September 28, 2010, at 11 a.m.
Ernst Schering Foundation | Unter den Linden 32-34 | 10117 Berlin | Germany

Presentations of the prize winners
September 29, 2010, at 10 a.m.
lecture to high school students in Berlin-Tegel, non-public event
"Identification of a molecule that revolutionised treatment of disabling arthritis"

September 29, 2010, at 4 p.m.
Public lecture for scientists and students
"Discovering a molecular therapy for chronic inflammatory arthritis"
Charité Universitätsmedizin Berlin - Hörsaal Südflügel
Sauerbruchweg 2 | 10117 Berlin
This lecture will be in English. A registration is not necessary.

Photo: Ravinder N. Maini (l) und Marc Feldmann (r)
© Kennedy Institute of Rheumatology, London 2010

Ernst Schering Preisträger 2010


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