Philipp Lachenmann: DELPHI Rationale


Ernst Schering Prize 2016

Proteins perform a variety of essential tasks in all cells of our body. In order to fulfill their biological functions, these chain-like molecules must fold into specific three-dimensional patterns. This process was originally thought to occur spontaneously. However, work by Prof. Dr. Franz-Ulrich Hartl, director of the Cellular Biochemistry Department at the Max Planck Institute of Biochemistry in Martinsried, showed that in our cells protein folding is mediated by helper molecules. These helper molecules are called chaperones, since these molecules make sure that proteins behave, i.e. fold, correctly. Incorrectly folded proteins tend to clump together to aggregates, which disturb cell functions in various ways and can cause neurodegenerative pathologies, such as Alzheimer’s dementia, Parkinson’s and Huntington’s disease. The insight that age-related diseases are caused by incorrectly folded proteins offers opportunities for novel therapeutic approaches. Prof. Hartl’s current research particularly focuses on these therapeutic approaches.

For his outstanding research on the role of chaperones in protein folding in living cells, the Ernst Schering Foundation presents Prof. Dr. Franz-Ulrich Hartl with the Ernst Schering Prize 2016. The festive award ceremony will take place on September 26, 2016, in Berlin.

Professor Hartl was nominated for the Ernst Schering Prize 2016 by Prof. Dr. Helmut Sies (Heinrich Heine University Düsseldorf), Prof. Dr. Wolfgang Baumeister (Max Planck Institute of Biochemistry in Martinsried), and Prof. Dr. Nikolaus Pfanner (University of Freiburg). Professor Sies, who will give the presentation speech at the award ceremony, says about Hartl’s work: “Franz-Ulrich Hartl’s outstanding research deserves the highest recognition. It combines fundamental new insights into the homeostasis of correctly folded proteins with new perspectives on the development and progression of neurodegenerative diseases, which may lead to innovative therapeutic approaches.”

Award Ceremony

September 26, 2016, 6:30 p.m.
Meistersaal at Potsdamer Platz
Köthener Straße 38 | 10963 Berlin

Registration until September 15, 2016, at: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

The prize will be awarded together with the 2016 Friedmund Neumann Prize of the Ernst Schering Foundation.

Lectures by the Award Winner

September 23, 2016 (not open to the public)
Lecture at Schulfarm Insel Scharfenberg, Berlin-Tegel

September 23, 2016, 2 p.m.
Public Scientific Lecture with Prof. Dr. Franz-Ulrich Hartl
Molecular Chaperones: Their Role in Protein Folding and Neurodegenerative Disease
Freie Universität Berlin
Lecture Hall Inorganic Chemistry (H101)
Fabeckstr. 34-36 | 14195 Berlin

The lecture is aimed at scientists and students and will be in English. Registration is not required.



pdf CV von Prof. Hartl

pdf Press_release




  Video about the Award Winner


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